Malaria y la resistencia a antimalaricos

Abstract

The Plasmodium falciparum resistance to antimalarial drugs is one of the contributing factors which influence the increasing prevalence of malaria all over the world. The appearance of parasite strain resistance to chloroquine conducted to the development of new drugs to which the plasmodium had also created resistance. Now a days the combination pyrimethamine-sulfadoxine in addition toamodiaquine is so far the therapeutic form used when there is chloroquine resistance; however resistance to pirimethamine-sulfadoxine has been already reported in some endemic regions. The resurgence and fast dispead of this resistance is the main reason for the development and improvement of diferentstrategies for its study so as the resistance determination In vivo evaluation of the parasite strain sensitivity to drugs and molecular test such as genetic polymorphism studies. But a low correlation was founded between theIn vivo prevalence and In vitro resistance to antimalarial drugs. Trends inmalaria on the relationship between parasite genotype and clinical outcome would alow the use molecular test to obtain information on treatment failure with antimalarial drugs in endemic zones.