Principales alteraciones de homeostasis en la diabetes mellitus

Abstract

The diabetes mellitus is defined as a endocrine affection or metabolic syndrome that consists of the deficiency, absence or resistance to the insulin, characterized by systemic physiophatogenia that includes neuropathies, retinopathies, hyperlipidemics, micro and macroangiophaties, hemopathies, cardiopathies and cataracts, among others. Due to the great variety of manifestations it is important to know the involved physiological foundations in the alterations the homeostasis the diabetic patient. These must mainly to the constant been of hyperglycemia, that entails to a series of non enzymatic spontaneous reactions, denominated protein glicosilación. Of this form, although the  glucose is the immediate source of energy on the part of the cells, their high concentrations (postprandial 140 mg/dL) becomes the promoter of the injuries to the different organs.