Keywords
Neisseria meningitidis
meningitis
sepsis
disseminated intravascular coagulation.
How to Cite
Abstract
The infection caused by Neisseria meningitidis is responsible of a big proportion of meningitis cases and sepsis in children and young adults around the world. The most frequent clinical features of meningococcal disease are meningitis and meningococcemia, although this last one is not the most frequent. The meningococcemia without meningitis presents in 1 of each 5 people who had the infection, and it reports mortality rates about 5% to 20%. We present a case of meningococcemia without meningitis associated to intravascular disseminated coagulation with successful recovery and without different sequelaes as described on literature.References
Takada S, Fujiwara S, Inoue T, Kataoka Y, Hadano Y, Matsumoto K, et al. Meningococcemia in adults: a review of the literature. Intern Med. 2016;55(6):567-72.
Koyfman A, Takayesu JK. Meningococcal disease. African Journal of Emergency Medicine. 2011;1(4):174-8.
Stephens DS, Greenwood B, Brandtzaeg P. Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet 2007;369(9580):2196–210.
Vélez-van-Meerbeke A, Medina-Silva N, Besada-Lombana S, Mojica-Madero JA. Epidemiología de la enfermedad por meningococo en Colombia. Infectio. 2016;2(4):1-7.
Pace D, Pollard AJ. Meningococcal disease: Clinical presentation and sequelae. Vaccine. 2012;30(Suppl 2):B3-9.
Horino T, Kato T, Sato F, Sakamoto M, Nakazawa Y, Yoshida M, et al. Meningococcemia without Meningitis in Japan. Intern Med. 2008;47(17):1543-7.
Herzog JL, Morgan KP, Paden MH, Stone PA. Disseminated intravascular coagulation, meningococcal infection, and ischemic changes affecting the lower extremities: a case study. J Foot Ankle Surg. 2010;49(5):489.e5-9.
van Ravenhorst MB, Bijlsma MW, van Houten MA, Struben AS, J. Eiden A, et al, Meningococcal carriage in Dutch adolescents and young adults; a cross-sectional and longitudinal cohort study. Clin Microbiol Infect. 2017pii: S1198-743X(17)30096-4.
Poizeau F, Cormerais M, Darrieux L, Ricordel S, Garnier G, Safa G. Meningococcemia without meningitis: A report of two cases. Rev Med Interne. 2016;37(3):206-8.
Duggal S, Duggal N, Charoo H, Mahajan RK. Recent outbreak of meningococcal meningitis--a microbiological study with brief review of literature. J Commun Dis. 2007;39(4):209-16.
Rosenstein NE, Perkins BA, Stephens DS, Popovic T, Hughes JM. Meningococcal disease. N Engl J Med. 2001;344(18):1378-88.
Rienk Nieuwland, René J. Berckmans, Sarah McGregor, Anita N. Böing, Fred P. H. Th. M. Romijn, Rudi G. J. Westendorp, et al, Cellular origin and procoagulant properties of microparticles in meningococcal sepsis. Blood.2000;95(3):930-5.
Faust SN, Levin M, Harrison OB, Goldin RD, Lockhart MS, Kondaveeti S, et al. Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis. New England Journal of Medicine. 2001;345(6): 408-16.
Agudelo CI. Aislamientos invasores de Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Colombia. Resultados de la vigilancia por departamentos SIREVA II 2003-2012; 2013. Disponible en: http://www.ins.gov.co/Noticias/SiteAssets/Paginas/SIREVA-II-Colombia-2003-2012/SIREVA%20II %20Colombia%202003-2012.pdf
Nadel S, Kroll JS. Diagnosis and management of meningococcal disease: the need for centralized care. FEMS Microbiol Rev. 2007;31(1):71-83.
Ridpath A, Greene SK, Robinson BF, Weiss D. Risk Factors for Serogroup C Meningococcal Disease during Outbreak among Men who Have Sex with Men, New York City, New York, USA. Emerging Infectious Diseases. 2015;21(8):1458-61.