Keywords
against the snake plants
phospholipases A2
How to Cite
Abstract
In Colombia the species Bothrops asper and Bothrops atrox are responsible for 70 to 90% of the snakebite accidents. Around 60% of these injuries are initially treated by traditional healers; they’re used medicinal plants in different preparations. This study evaluated the inhibitory capacity in five vegetables species against proteolytic and hemolytic indirect effect induced by the venom of B. asper in vitro. The species that were selected according to their use in traditional medicine by the rural communities of the Sierra Nevada de Santa Marta are: Aristolochia maxima Cissampelospareira, Equisetum bogotense, Mucunacfpruriens and Austroeupatoriuminulaefolium. E. bogotense showed the highest percentage of inhibition in opposition to the activity of Phospholipases A2 (42.29%), also the higher precipitation of proteins in a range of molecular weights from 28.2 to 94.43 KDa. Fractionating the extract of E. bogotense we obtained five fractions, which showed an inhibition percentage from 36.6 ± 1.07 to 46.1± 13.6. Additionally, we detected some nucleus by qualitative methods, principally alkaloids, steroids and/or triterpenes, tannins, coumarins and leucoanthocyanidins. In the study reported activity in vitro assays of the species E.bogotense against the venom of the species B. asper.References
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