Edad y recuento leucocitario como factores pronósticos en leucemia linfoblástica aguda: cohorte hgmla07
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Ladines-Castro, W., Santoyo-Sánchez, A., Rozen-Fuller, E., Olarte-Carrillo, I., Martínez-Tovar, A., Castellanos-Sinco, H., Collazo-Jaloma, J., & Ramos-Peñafiel, C. O. (2016). Edad y recuento leucocitario como factores pronósticos en leucemia linfoblástica aguda: cohorte hgmla07. Duazary, 13(2), 142 - 148. https://doi.org/10.21676/2389783X.1720

Resumen

Con el objetivo de establecer la cifra de corte de leucocitos y edad con implicación pronostica en adultos con leucemia linfoblástica aguda (LLA), se efectuó un estudio observacional, descriptivo y analítico anidado en la cohorte retrospectiva de pacientes con LLA tratados mediante el protocolo institucional HGMLAL07 durante 2007-2014. Se estudiaron 255 pacientes, el 52.9% (n=135) correspondieron al género femenino y 47.1% (n=120) al género masculino. La media de edad fue de 31 (16-80) años. La supervivencia libre de la enfermedad (SLE) disminuyó en ambos géneros a partir de los 20 años (p=0.001). La media de leucocitos fue 56.1 x 109/L (0.1-850 x 109/L). La SLE disminuyó significativamente a partir de una cifra igual o mayor de 20 x 109/L (p<0.05). Con esto se puede concluir que emplear puntos de corte para leucocitos y edad obtenidos en poblaciones distintas pudiera condicionar una mala clasificación pronostica y un consiguiente tratamiento subóptimo.

Palabras clave

Edad de Inicio, Leucemia-Linfoma Linfoblástica de Células Precursoras, Pronóstico, Recuento de Leucocitos, Supervivencia sin Enfermedad
https://doi.org/10.21676/2389783X.1720
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